A dark and brooding creature of the night, William Cuyler Thorne has spent five centuries mourning the deaths of his beloved wife and son. In that time, he has also grown into Savannah's most powerful vampire, attracting rich, beautiful women and commanding fear in all who dare cross is path. Now he seeks revenge. For it appears that his wife and son are not dead, but rather undead, having joined a malicious clan of European bloodsuckers—and that same group has now captured Renee, the young daughter of his dear friend, a voodoo princess. Leaving his suave sidekick, Jack, to hold down the fort in Savannah, William travels across the Atlantic to save Renee and settle the score.

While Jack is left to contend with his seductive ex-girlfriend and a rebellious band of werewolves, William must confront his own defiant temptress and an even more sinister threat. For the evil vampire lords will do much more than retaliate if William rescues Renee and her magical blood: They will wreak havoc across the land.