It didn't start out as the worst day of Natalie Miller's life. At thirty, she is moving up the political ladder, driven by raw ambition and ruthless determination. As the top aide to New York's powerful female senator, she works hard, stays late, and enjoys every bit of it, even if the bills she's pushing through do little to improve the lives of the senator's constituents. And if her boyfriend isn't the sexiest guy alive, at least he's a warm body to come home to.

Then he announces he's leaving. But that news is barely a blip compared to what Natalie's doctor tells her: She has breast cancer. And she can't cure it by merely being headstrong. Now the life Natalie must change is her own.

All her energy, what little of it she has left, must go into saving herself from a merciless disease. So when she's not lying on the sofa recovering from her treatments and indulging in a curious addiction to The Price Is Right, she realizes it's time to take a hard look at her choices. She begins by tracking down the five loves-of-her-life to assess what went wrong. Along the way, she questions her relationships with her friends, her parents, her colleagues, the one who got away, and, most important, with herself: Why is she so busy moving through life that she never stops to embrace it?

As Natalie sleuths out the answers to these questions, her journey of self-discovery takes her down new paths and to unexplored places. And she learns that sometimes when life is at its most unexpected, it's not what you lose that makes you who you are . . . it's what you find.